Feb 23, 2020 · 2.1. Synthesis of the Isothiazolinone Derivatives MI, MCI, OIT, and DCOIT. A number of protocols can be found in the literature describing the synthesis of MI, MCI, and OIT biocides from the cyclization of either thioacrylamides or 3,3′-dithiopropionamides [11,12,13,14].The first synthesis of 2-methylisothiazol-3(2H)-one (MI) was reported by Crow and Leonard in 1964 …
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